Methanethiol → HCID 14809494、化合物

HRID 649311ノート

反応式

HRID 649311 の反応式
Cl[C:2]1([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[OH:22])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1.[CH3:23][SH:24]>O1CCCC1>[OH:22][C:15]1[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:2]1([S:24][CH3:23])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1

参加物

4

反応物 2

HCID 878MethanethiolHCID 14809492HCID 14809492、化合物

生成物 1

HCID 14809494HCID 14809494、化合物収率 78.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2-Chloro-3,4-dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (12.3 g, compound No. 3) is added to a mixture of 30% aqueous methyl mercaptan solution (26 ml) and tetrahydrofuran (50 ml). The mixture is stirred for 1.5 hours at room temperature and concentrated in vacuo. The separated crystals are collected by filtration to give 10.0 g (78.3%) of the titled compound.

後処理

  1. concentrationconcentrated in vacuo
  2. filtrationThe separated crystals are collected by filtration

出典と根拠

ORDレコード
ord-e7ac83adb3084309bbc6d48504431d6f
出典データセット
uspto-grants-1988_04
特許番号
US04739050

反応ノート

読み込み中…