Silica → Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate

HRID 649364

反応式

HRID 649364 の反応式
[Cl:1][CH2:2][O:3][C:4](F)(F)[CH:5]([C:10]([F:13])([F:12])[F:11])[C:6]([F:9])([F:8])[F:7].[Si](=O)=[O:17].S(F)(=O)(=O)O>>[F:7][C:6]([F:9])([F:8])[CH:5]([C:10]([F:13])([F:12])[F:11])[C:4]([O:3][CH2:2][Cl:1])=[O:17]

参加物

4

反応物 3

HCID 24261SilicaHCID 24603Fluorosulfuric acidHCID 138276951-Chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane

生成物 1

HCID 13954659Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate

実験手順

In a four necked 1 liter flask equipped with a thermometer, a condenser and a stirrer, 1-chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane (276.6 g, 1.04 mol), silicon dioxide and fluorosulfuric acid (70.0 g, 0.70 mol) were charged. The reaction was continued at 110° C. for 21 hours. Then, the reaction mixture was distilled to give monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (190.3 g).

後処理

  1. additionwere charged
  2. distillationThen, the reaction mixture was distilled

出典と根拠

ORDレコード
ord-67f3276e23bd42eca843b0360413ae7f
出典データセット
uspto-grants-1988_04
特許番号
US04739123

関連ノート

読み込み中…