Hydrochloric Acid → 4-Dimethylaminobenzyl alcohol
反応式
[CH3:1][N:2]([CH3:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[O:8])=[CH:5][CH:4]=1.[BH4-].[Na+].Cl>C(O)C>[CH3:1][N:2]([CH3:11])[C:3]1[CH:10]=[CH:9][C:6]([CH2:7][OH:8])=[CH:5][CH:4]=1参加物
5
実験手順
Mix 4-dimethylaminobenzaldehyde (3.3 g, 22 mmol), sodium borohydride (830 mg, 22 mmol) and absolute ethanol (25 mL). Stir at room temperature until the reaction is complete, pour onto dilute hydrochloric acid and extract into ethyl acetate. Separate the organic phase and extract the aqueous phase with ethyl acetate (2×). Combine the organic phases and dry (MgSO4). Evaporate the solvent in vacuo and purify by silica gel chromatography to give 4-(dimethylamino)benzyl alcohol.
後処理
- extractionextract into ethyl acetate
- customSeparate the organic phase
- extractionextract the aqueous phase with ethyl acetate (2×)
- dry with materialCombine the organic phases and dry (MgSO4)
- customEvaporate the solvent in vacuo
- custompurify by silica gel chromatography
出典と根拠
- ORDレコード
- ord-d66256aab42c4645ba01c94ac4791f03
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05248825
反応ノート
読み込み中…