Hydrochloric Acid → 4-Dimethylaminobenzyl alcohol

HRID 6496

反応式

HRID 6496 の反応式
[CH3:1][N:2]([CH3:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[O:8])=[CH:5][CH:4]=1.[BH4-].[Na+].Cl>C(O)C>[CH3:1][N:2]([CH3:11])[C:3]1[CH:10]=[CH:9][C:6]([CH2:7][OH:8])=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 74794-(Dimethylamino)BenzaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 1371664-Dimethylaminobenzyl alcohol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Mix 4-dimethylaminobenzaldehyde (3.3 g, 22 mmol), sodium borohydride (830 mg, 22 mmol) and absolute ethanol (25 mL). Stir at room temperature until the reaction is complete, pour onto dilute hydrochloric acid and extract into ethyl acetate. Separate the organic phase and extract the aqueous phase with ethyl acetate (2×). Combine the organic phases and dry (MgSO4). Evaporate the solvent in vacuo and purify by silica gel chromatography to give 4-(dimethylamino)benzyl alcohol.

後処理

  1. extractionextract into ethyl acetate
  2. customSeparate the organic phase
  3. extractionextract the aqueous phase with ethyl acetate (2×)
  4. dry with materialCombine the organic phases and dry (MgSO4)
  5. customEvaporate the solvent in vacuo
  6. custompurify by silica gel chromatography

出典と根拠

ORDレコード
ord-d66256aab42c4645ba01c94ac4791f03
出典データセット
uspto-grants-1993_09
特許番号
US05248825

関連ノート

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