Water → 12-Acetyl-5-methoxy-12H-benzo[a]phenothiazine

HRID 64963ノート

反応式

HRID 64963 の反応式
[CH3:1]C(C)([O-])C.[K+].[C:7]([N:10]1[C:23]2[C:18](=[CH:19][C:20]([OH:28])=[C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]3=2)[S:17][C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)(=[O:9])[CH3:8].CI.O>CN(C=O)C>[C:7]([N:10]1[C:23]2[C:18](=[CH:19][C:20]([O:28][CH3:1])=[C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]3=2)[S:17][C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)(=[O:9])[CH3:8]

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 1371248512-acetyl-5-hydroxy-12H-benzo[a]phenothiazineHCID 23665647Potassium tert-butoxide

生成物 1

HCID 1371248612-Acetyl-5-methoxy-12H-benzo[a]phenothiazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Potassium tert-butoxide (800 mg) was added to a solution of 12-acetyl-5-hydroxy-12H-benzo[a]phenothiazine (950 mg) (from Example 3) and methyl iodide (1.5 ml) in DMF (10 ml) and stirred for 15 minutes. Water (80 ml) was added to the reaction mixture and the precipitate was filtered to afford the title compound.

後処理

  1. filtrationthe precipitate was filtered

出典と根拠

ORDレコード
ord-b694f4419f0c49708dc08209ccec080e
出典データセット
uspto-grants-1986_09
特許番号
US04611056

反応ノート

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