Hydrochloric Acid → 4-Methyl-1,2,3-thiadiazole-5-carboxylic acid

HRID 649864

反応式

HRID 649864 の反応式
C[O:2][C:3]([C:5]1[S:9][N:8]=[N:7][C:6]=1[CH3:10])=[O:4].[OH-].[Na+].Cl>CO>[CH3:10][C:6]1[N:7]=[N:8][S:9][C:5]=1[C:3]([OH:4])=[O:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 7576666Methyl 4-methyl-1,2,3-thiadiazole-5-carboxylate

生成物 1

HCID 13819924-Methyl-1,2,3-thiadiazole-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid methyl ester (1.7 g) is dissolved in methanol (15 mL) and treated with 1N sodium hydroxide (16 mL). After stirring at room temperature for 1 hour, the reaction is treated with concentrated hydrochloric acid (1.5 mL) and concentrated under reduced pressure. The resulting turbid aqueous layer is extracted twice with diethyl ether and the pooled organic layers are dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the desired compound as a white powder.

後処理

  1. concentrationconcentrated under reduced pressure
  2. extractionThe resulting turbid aqueous layer is extracted twice with diethyl ether
  3. dry with materialthe pooled organic layers are dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-3a3e4431c7854b1cb2bf23ba0601180c
出典データセット
uspto-grants-2001_08
特許番号
US06271236B1

関連ノート

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