Dimethylformamide dimethyl acetal → Ethyl 3-(dimethylamino)-2-isocyanoacrylate
反応式
[N+:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[C-:2].CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>C(O)C>[CH2:7]([O:6][C:4](=[O:5])[C:3]([N+:1]#[C-:2])=[CH:11][N:12]([CH3:14])[CH3:13])[CH3:8]参加物
4
実験手順
To a solution of ethyl isocyanoacetate (5.0 g) in ethanol (100 mL) is added N,N-dimethyl-formamide dimethyl acetal (6.5 g) dropwise with stirring over 10 minutes. The reaction is stirred for 24 hours and the ethanol is evaporated. The resulting oil is passed through magnesium silicate using 50% ethyl acetate-hexanes as the eluant. The solvents are removed and the resulting oil is crystallized from ethyl acetate-hexanes to yield light yellow needles, 3.0 g.
後処理
- stirringThe reaction is stirred for 24 hours
- customthe ethanol is evaporated
- customThe solvents are removed
- customthe resulting oil is crystallized from ethyl acetate-hexanes
- customto yield light yellow needles, 3.0 g
出典と根拠
- ORDレコード
- ord-5dbbb5b6d6f149409e2f95da9a895b3e
- 出典データセット
- uspto-grants-2001_08
- 特許番号
- US06271236B1
反応ノート
読み込み中…