Thionyl Chloride → N-(4-fluoro-2-hydroxyphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide

HRID 649985ノート

反応式

HRID 649985 の反応式
[Br:1][C:2]1[S:3][C:4]([CH3:10])=[CH:5][C:6]=1[C:7]([OH:9])=O.S(Cl)(Cl)=O.[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=1[OH:23]>>[F:22][C:19]1[CH:20]=[CH:21][C:16]([NH:15][C:7]([C:6]2[CH:5]=[C:4]([CH3:10])[S:3][C:2]=2[Br:1])=[O:9])=[C:17]([OH:23])[CH:18]=1

参加物

4

反応物 3

HCID 24386Thionyl ChlorideHCID 1857632-Amino-5-fluorophenolHCID 111175892-Bromo-5-methylthiophene-3-carboxylic acid

生成物 1

HCID 18422331N-(4-fluoro-2-hydroxyphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide

実験手順

In the same manner as in Starting Material Synthesis Example 67 and using 2-bromo-5-methyl-3-thiophenecarboxylic acid, thionyl chloride and 2-amino-5-fluorophenol, N-(4-fluoro-2-hydroxyphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide is obtained.

後処理

  1. customMaterial Synthesis Example 67

出典と根拠

ORDレコード
ord-df430c840f4642f8b2ec8285e73ad4f0
出典データセット
uspto-grants-2001_08
特許番号
US06271225B1

反応ノート

読み込み中…