Thionyl Chloride → N-(2-hydroxy-3-methylphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide

HRID 649986ノート

反応式

HRID 649986 の反応式
[Br:1][C:2]1[S:3][C:4]([CH3:10])=[CH:5][C:6]=1[C:7]([OH:9])=O.S(Cl)(Cl)=O.[NH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:17]=1[OH:23]>>[OH:23][C:17]1[C:18]([CH3:22])=[CH:19][CH:20]=[CH:21][C:16]=1[NH:15][C:7]([C:6]1[CH:5]=[C:4]([CH3:10])[S:3][C:2]=1[Br:1])=[O:9]

参加物

4

反応物 3

HCID 24386Thionyl ChlorideHCID 4136576-Amino-o-cresolHCID 111175892-Bromo-5-methylthiophene-3-carboxylic acid

生成物 1

HCID 11001920N-(2-hydroxy-3-methylphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide

実験手順

In the same manner as in Starting Material Synthesis Example 67 and using 2-bromo-5-methyl-3-thiophenecarboxylic acid, thionyl chloride and 2-amino-6-methylphenol, N-(2-hydroxy-3-methylphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide is obtained.

後処理

  1. customMaterial Synthesis Example 67

出典と根拠

ORDレコード
ord-2ab6816da0834bb498817f25c6067255
出典データセット
uspto-grants-2001_08
特許番号
US06271225B1

反応ノート

読み込み中…