1,2-Dichloroethane → 2-acetylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one

HRID 650002ノート

反応式

HRID 650002 の反応式
[S:1]1[C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=[CH:2]1.ClCCCl.[C:20](Cl)(=[O:22])[CH3:21].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)(Cl)Cl>[C:20]([C:2]1[S:1][C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=1)(=[O:22])[CH3:21]

参加物

6

反応物 4

HCID 111,2-DichloroethaneHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 18422172Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one

生成物 1

HCID 184223372-acetylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one (5 g) was suspended to 1,2-dichloroethane (50 ml) and acetyl chloride was added (2.2 g). To this reaction system was added portionwise aluminum chloride (15 g) under ice-cooling and the mixture was stirred at room temperature for 10 minutes. The reaction system was poured into ice. Chloroform was added and the mixture was stirred for 15 minutes. The precipitated crystals were collected by filtration to give 2-acetylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one (5.2 g).

後処理

  1. additionwas added (2.2 g)
  2. temperaturecooling
  3. additionThe reaction system was poured into ice
  4. stirringthe mixture was stirred for 15 minutes
  5. filtrationThe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-8a9a0fab71fd41de85f86f46ccd60960
出典データセット
uspto-grants-2001_08
特許番号
US06271225B1

反応ノート

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