Water → 5-Methyloctahydro-1H-4,7-methanoinden-5-ol

HRID 650297

反応式

HRID 650297 の反応式
[CH:1]12[CH2:11][CH:7]([C:8](=[O:10])[CH2:9]1)[CH:6]1[CH:2]2[CH2:3][CH2:4][CH2:5]1.[CH3:12][Mg]Cl.O>O1CCCC1>[CH3:12][C:8]1([OH:10])[CH2:9][CH:1]2[CH2:11][CH:7]1[CH:6]1[CH:2]2[CH2:3][CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 962Water2 回HCID 965094,7-Methano-5H-inden-5-one, octahydro-HCID 178418332HCID 178418332、化合物

生成物 1

HCID 134625055-Methyloctahydro-1H-4,7-methanoinden-5-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒3 回

実験手順

Tricyclo [5.2.1.02,6] decan-8-one (15.0 g) in tetrahydrofuran (THF, 50 ml) is slowly added into CH3MgCl (9.7 g) in THF and the reaction mixture is stirred completely. Tetrahydrofuran (THF, 100 ml) with 5% of water is added into the reaction mixture. Then 100 ml of water is added to the reaction mixture. The reaction mixture is extracted by ether. The organic extract is concentrated in vacuo to yield 8-methyl-tricyclo [5.2.1.02,6] decan-8-ol (formula (X)) as white solid.

後処理

  1. extractionThe reaction mixture is extracted by ether
  2. extractionThe organic extract
  3. concentrationis concentrated in vacuo

出典と根拠

ORDレコード
ord-ad544c725db040258fa7900dde80a2eb
出典データセット
uspto-grants-2001_08
特許番号
US06271412B1

関連ノート

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