C[O:2][C:3]([CH2:5][CH2:6][CH2:7][C:8]1[S:9][C:10]([C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[N:12]=1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[OH:2][CH2:3][CH2:5][CH2:6][CH2:7][C:8]1[S:9][C:10]([C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)=[C:11]([C:13]2[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[CH:17][CH:18]=2)[N:12]=1In 10 ml of tetrahydrofuran was dissolved 770 mg of 2-(3-methoxycarbonylpropyl)-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole prepared by example 4, which was then cooled with ice. To the solution was added little by little 100 mg of lithium aluminium hydride, which was stirred for one hour. To the mixture was added water, which was subjected to extraction with ethyl acetate. The organic layer was washed with water, dried and concentrated, followed by purifying by means of a silica-gel chromatography [chloroform-methanol (9:1)] to yield 576 mg (81%) of 2-(4-hydroxybutyl)-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole as an oily substance.
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