Thionyl Chloride → 3-Chloro-5-trifluoromethyl-pyridine-2-carbonyl chloride
反応式
[Cl:1][C:2]1[C:3]([C:12]([OH:14])=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.S(Cl)([Cl:17])=O>>[Cl:1][C:2]1[C:3]([C:12]([Cl:17])=[O:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1参加物
3
反応条件
- 温度
- 25 °C
実験手順
89.3 g of 3-chloro-5-trifluoromethyl-2-pyridinecarboxylic acid (Example P3) are slowly heated to reflux with 60 ml of thionyl chloride and the mixture is then stirred at that temperature for 4 hours, after which it is cooled to 25° C. and concentrated to dryness in vacuo. Twice, toluene is added and the mixture is again concentrated to dryness. 94.0 g of the desired product are obtained in the form of a yellow residue.
後処理
- concentrationconcentrated to dryness in vacuo
- additionTwice, toluene is added
- concentrationthe mixture is again concentrated to dryness
出典と根拠
- ORDレコード
- ord-ad87a9bcb6d84ff58a1cd54544b1e42f
- 出典データセット
- uspto-grants-2001_08
- 特許番号
- US06274536B1
反応ノート
読み込み中…