反応式
[OH:1][CH2:2][C@@H:3]1[CH2:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[C@H:5]([CH3:16])[NH:4]1.C(N([CH2:22][CH3:23])CC)C.[C:24](=[S:26])=[S:25].C(I)C>CO.O>[OH:1][CH2:2][C@@H:3]1[CH2:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[C@H:5]([CH3:16])[N:4]1[C:24]([S:26][CH2:22][CH3:23])=[S:25]参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
In the same manner as described in Example 13 by using (1S, 3S)-3-hydroxymethyl-1-methyl-1,2,3,4-tetrahydro-β-carboline (1.08 g), triethylamine (1.01 g), CS2 (0.76 g), ethyl iodide (1.56 g), methanol (25 ml) and water (2.5 ml), there is prepared the title compound (1.25 g, 78%) as white powder, [α]D20 +176.0° (c=1, methanol). NMR (CDCl3, δ): 1.38 (t, J=7.3 Hz, 3H, CSSCH2CH3), 1.62 (d, J=6.8 Hz, 3H, C1 --CH3), Mass m/e: 320 (M+), 291 (M+ --C2H5), 258 (M+ --C2H5SH).
出典と根拠
- ORDレコード
- ord-96e6c2fceeed40d08ca3899aca60f24e
- 出典データセット
- uspto-grants-1986_09
- 特許番号
- US04612317
関連ノート
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