1-Benzyl-4-(pyridin-2-YL)piperidin-4-OL → 4-(2-Pyridinyl)-4-piperidinol
反応式
C([N:8]1[CH2:13][CH2:12][C:11]([OH:20])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CCO>[OH:20][C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1参加物
4
実験手順
A mixture of N-benzyl-4-hydroxy-4-(2-pyridyl)piperidine (1.2 g, 4.48 mmol), 20% Pd—C (0.2 g) and EtOH (100 mL) was stirred at H2 (150 psi ) for 36 h. The catalyst was removed by filtration and washed with more ethanol. Solvent was evaporated to give pure 4-hydroxy-4-(2-pyridyl)piperidine (0.75 g, 94%).
後処理
- customThe catalyst was removed by filtration
- washwashed with more ethanol
- customSolvent was evaporated
出典と根拠
- ORDレコード
- ord-882adc71092c4cdaab0e221b353f3d99
- 出典データセット
- uspto-grants-2001_08
- 特許番号
- US06274585B1
反応ノート
読み込み中…