1,2-Benzenedicarbonitrile, 4-nitro- → 1,2-Benzenedicarbonitrile, 4-amino-

HRID 650687

反応式

HRID 650687 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[CH:10][CH:11]=1)[C:8]#[N:9])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[CH:10][CH:11]=1)[C:8]#[N:9]

参加物

4

反応物 1

HCID 974431,2-Benzenedicarbonitrile, 4-nitro-

生成物 1

HCID 925291,2-Benzenedicarbonitrile, 4-amino-収率 86%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A portion of 4-nitrophthalonitrile (5.15 g, 29.8 mmole) was dissolved in 125 mL methanol in a hydrogenation flask. The catalyst, 10% Pd/C (515 mg), was added to the mixture which was thin flushed with H2 and stirred under 50 psi of H2 for 1 hour. The catalyst was removed by filtration and the solvent was distilled off under vacuum. The desired 4-aminophthalonitrile was obtained in 86% yield (3.668 g).

後処理

  1. customwas thin flushed with H2
  2. customThe catalyst was removed by filtration
  3. distillationthe solvent was distilled off under vacuum

出典と根拠

ORDレコード
ord-cb716531ed144d7c8b4485d113110471
出典データセット
uspto-grants-2001_08
特許番号
US06274729B1

関連ノート

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