Phosgene → N-(2,4-Dimethylthiophen-3-yl)-N-n-propylcarbamoyl chloride

HRID 650873

反応式

HRID 650873 の反応式
[C:1]([Cl:4])(Cl)=[O:2].[CH3:5][C:6]1[S:7][CH:8]=[C:9]([CH3:15])[C:10]=1[NH:11][CH2:12][CH2:13][CH3:14].C(N(CC)CC)C>>[CH3:5][C:6]1[S:7][CH:8]=[C:9]([CH3:15])[C:10]=1[N:11]([CH2:12][CH2:13][CH3:14])[C:1]([Cl:4])=[O:2]

参加物

4

反応物 3

HCID 6371PhosgeneHCID 8471TriethylamineHCID 217099312,4-Dimethylthiophen-3-yl-(n-propyl)amine

生成物 1

HCID 53969524N-(2,4-Dimethylthiophen-3-yl)-N-n-propylcarbamoyl chloride

実験手順

54.5 g (0.54 mol) of phosgene, 31 g (0.18 mol) of 2,4-dimethylthiophen-3-yl-(n-propyl)amine and 18.5 g (0.18 mol) of triethylamine were reacted similarly to the process described in Intermediate 1.2. Yield 40 g. MS (m/z): 231 [M]+, 202 [M−C2H5]+, 196 [M−Cl]+.

出典と根拠

ORDレコード
ord-bfa1021f3b3e45458ef08f6784f9f8f8
出典データセット
uspto-grants-2001_08
特許番号
US06277790B1

関連ノート

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