Phosgene → N-methyl-N-(oxan-4-yl)carbamoyl chloride

HRID 650874

反応式

HRID 650874 の反応式
[C:1]([Cl:4])(Cl)=[O:2].[CH3:5][NH:6][CH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1.C(N(CC)CC)C>>[CH3:5][N:6]([CH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)[C:1]([Cl:4])=[O:2]

参加物

4

反応物 3

HCID 6371PhosgeneHCID 8471TriethylamineHCID 69919504-(Methylamino)tetrahydro-2H-pyran

生成物 1

HCID 21709910N-methyl-N-(oxan-4-yl)carbamoyl chloride

実験手順

248 g (2.5 mol) of phosgene, 96 g (0.83 mol) of N-methyl-N-(tetrahydro-2H-pyran-4-yl)amine and 84 g (0.83 mol) of triethylamine were reacted by the method of the process described in Intermediate 1.2. Yield 108 g. 1H NMR (250 MHz, in CDCl3): δ=1.60-1.95 (m, 4H), 2.94 and 3.01 (2 s, together 3H), 3.35-3.55 (rm, 2H), 3.95-4.10 (m, 2H), 4.27-4.46 (m, 1H).

出典と根拠

ORDレコード
ord-caaf391666dc4bf88eab3ccb9cad41de
出典データセット
uspto-grants-2001_08
特許番号
US06277790B1

関連ノート

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