Sodium borohydride → 5-Amino-1,2-dimethyl-1,2,3,4-tetrahydroisoquinoline
反応式
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]([CH3:13])[CH:7]2[CH3:12].[BH4-].[Na+]>CO>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:13])[CH:7]2[CH3:12]参加物
4
実験手順
To an ice cold solution of 5-amino-1,2-dihydro-1,2-dimethyl isoquinoline (4 g, 23.2 mmol) in methanol (80 ml) was added sodium borohydride (3.51 g, 92.8 mmol) portionwise. The mixture was allowed to stir at room temperature overnight before concentration in vacuo; the residue was then partitioned between water and dichloromethane. The organic layer was dried over sodium sulfate and concentrated in vacuo to afford a light brown oil (4.023 g).
後処理
- customthe residue was then partitioned between water and dichloromethane
- dry with materialThe organic layer was dried over sodium sulfate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-b4dbccc5d1234b439320822b802a636d
- 出典データセット
- uspto-grants-2001_08
- 特許番号
- US06277861B1
反応ノート
読み込み中…