2,4-Dimethoxybenzoic acid → 5-Bromo-2,4-dimethoxybenzoic acid

HRID 650958

反応式

HRID 650958 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[Br:14]Br>C(Cl)(Cl)Cl>[Br:14][C:9]1[C:10]([O:12][CH3:13])=[CH:11][C:3]([O:2][CH3:1])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]

参加物

4

反応物 2

HCID 70522,4-Dimethoxybenzoic acidHCID 24408Bromine

生成物 1

HCID 135050975-Bromo-2,4-dimethoxybenzoic acid収率 50%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a solution of 2,4-dimethoxybenzoic acid (4.0 g, 0.022 mol) in chloroform (60 ml) was added bromine (1.13 ml, 0.022 mol) in chloroform (20 ml) dropwise. After stiring overnight at room temperature the precipitate was filtered off and dried to afford the title compound as a white solid (2.87 g).

後処理

  1. filtrationthe precipitate was filtered off
  2. customdried

出典と根拠

ORDレコード
ord-8aeaaf75fafb491db2f817b3286f1927
出典データセット
uspto-grants-2001_08
特許番号
US06277861B1

関連ノート

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