Hydrochloric Acid → 1,3-Dibenzyloxy-2-chloromethoxypropane

HRID 65100

反応式

HRID 65100 の反応式
[ClH:1].[CH2:2]([O:9][CH2:10][CH:11]([CH2:13][O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[OH:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:22]=O>ClCCCl>[CH2:2]([O:9][CH2:10][CH:11]([CH2:13][O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[O:12][CH2:22][Cl:1])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 2476141,3-Bis(benzyloxy)propan-2-ol

生成物 1

HCID 111630061,3-Dibenzyloxy-2-chloromethoxypropane

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

反応条件

温度
21 °C

実験手順

Dry hydrogen chloride gas was bubbled for 1.5 hours into a solution of 1,3-di-O-benzylglycerol from Preparation I (15 g, 55 mmol) and paraformaldehyde (3.3 g, 110 mmol) in 175 ml of 1,2-dichloroethane at 0° C. The solution was then stored in a stoppered flask for 21 hours at 4° C. Next, the solution was dried over magnesium sulfate with warming to 21° C. then filtered and concentrated to give 17.5 g of 1,3-di-O-benzyl-2-O-chloromethylglycerol.

後処理

  1. dry with materialNext, the solution was dried over magnesium sulfate
  2. filtrationthen filtered
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-afb37040782a437c97d033556e9a2172
出典データセット
uspto-grants-1986_09
特許番号
US04612314

関連ノート

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