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Dimethylamine, hydrochloride → (s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 反応物 | 2-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid | HCID 14540322 | — |
| 生成物 | (s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester | HCID 54383962 | — |
反応手順
Dimethylamine hydrochloride (1.2 mmol) and Boc-L-3-(4-thiazolyl)alanine (1.0 mmol) were coupled according to Procedure A (0-25° C. reaction temperature) and the product purified by chromatography on silica gel eluted with 1-16% ethanol In dichloromethane containing 0.5% ammonium hydroxide. Yield 124 mg, 41%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06277877B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-d18d013b226a446b9def77135af71ba0 |
| 出典メモ | uspto-grants-2001_08 |