反应详情

Dimethylamine hydrochloride (1.2 mmol) and Boc-L-3-(4-thiazolyl)alanine (1.0 mmol) were coupled according to Procedure A (0-25° C. reaction temperature) and the product purified by chromatography on silica gel eluted with 1-16% ethanol In dichloromethane containing 0.5% ammonium hydroxide. Yield 124 mg, 41%.

1. customthe product purified by chromatography on silica gel
2. washeluted with 1-16% ethanol In dichloromethane containing 0.5% ammonium hydroxide