Bromine → (R)-(-)-5-Bromo-2-(1-methylheptyloxy)benzonitrile
反応式
[CH3:1][C@@H:2]([O:9][C:10]1[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=1[C:12]#[N:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].BrBr.[Br:20]C1C=CC(OC[C@@H](C)CC)=C(C=1)C#N>C(Cl)(Cl)Cl>[Br:20][C:15]1[CH:16]=[CH:17][C:10]([O:9][C@H:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])=[C:11]([CH:14]=1)[C:12]#[N:13]参加物
5
実験手順
Quantities: compound 40 (12.34 g, 0.054 mol), bromine (17.15 g, 0.0107 mol), chloroform (100 ml). The experimental procedure was as described for the preparation of compound 41. The crude product was purified by column chromatography (20% petrol/dichloromethane) to give a fawn oil.
後処理
- customThe crude product was purified by column chromatography (20% petrol/dichloromethane)
- customto give a fawn oil
出典と根拠
- ORDレコード
- ord-2852928170f24de9af50cd9536d74e04
- 出典データセット
- uspto-grants-2001_08
- 特許番号
- US06278028B1
反応ノート
読み込み中…