Thionyl Chloride → 4'-Chlorobiphenyl-4-sulfonyl chloride
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([OH:17])(=O)=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([Cl:20])(=[O:17])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1参加物
3
実験手順
A suspension of the 4′-chlorobiphenyl-4-sulfonic acid in 100 mL of thionyl chloride is heated at reflux for 6 h, and the resulting homogeneous solution is then cooled to RT. The mixture is concentrated under reduced pressure and the residue is triturated with diethyl ether and dried to afford 9.8 g (95%) of 4′-chlorobiphenyl-4-sulfonyl chloride as an off-white solid.
後処理
- temperatureis heated
- temperatureat reflux for 6 h
- concentrationThe mixture is concentrated under reduced pressure
- customthe residue is triturated with diethyl ether
- customdried
出典と根拠
- ORDレコード
- ord-b8add0fe30734fef9ae64c35dd7ef0ed
- 出典データセット
- uspto-grants-2001_08
- 特許番号
- US06277987B1
反応ノート
読み込み中…