Ethyl alpha-oxobenzenebutanoate → Ethyl 2-hydroxy-4-phenylbutyrate, (+-)-

HRID 651350

反応式

HRID 651350 の反応式
[CH2:1]([O:3][C:4](=[O:15])[C:5](=[O:14])[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:2].[H][H]>C1(C)C=CC=CC=1.CO>[CH2:1]([O:3][C:4](=[O:15])[CH:5]([OH:14])[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:2]

参加物

4

反応物 2

HCID 562087Ethyl alpha-oxobenzenebutanoateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 4092621Ethyl 2-hydroxy-4-phenylbutyrate, (+-)-

試薬・触媒・溶媒 1

HCID 21867641Toluene methanol溶媒

実験手順

The general procedure described in Example B1 is repeated, with the following modifications to the reaction conditions: ethyl-4-phenyl-2-oxobutyrate (substrate): 0.352 g (1.7 mmol); solvent: 10 ml of toluene/methanol (1:1); hydrogen: 50 bar, temperature: 50° C.; reaction time: 19 hours. The conversion is 100%, ee: 44% (R).

後処理

  1. customis repeated, with the following modifications to the reaction conditions
  2. custom50° C.
  3. customreaction time
  4. custom19 hours

出典と根拠

ORDレコード
ord-2a15d83e4c9a44eea74e25d3e9238d39
出典データセット
uspto-grants-2001_08
特許番号
USRE037344E1

関連ノート

読み込み中…