反応式
[CH3:1][C:2]1[O:3][C:4](=[O:14])[C:5](=[CH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:6]=1.[OH-:15].[Na+:16]>O>[C:2]([NH:6][C:5](=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([O-:3])=[O:14])(=[O:15])[CH3:1].[Na+:16]参加物
実験手順
In a 100-ml tightly-sealed glass vessel were charged 9.36 g of 2-methyl-4-benzylidene-5-oxazolone and 30 ml of water. Then, 5.3 g of 45% sodium hydroxide solution was added thereto and the resulting mixture was stirred at 40°-45° C. for two hours. The 2-methyl-4-benzylidene-5-oxazolone was hydrolyzed to form an aqueous homogeneous solution of sodium α-acetylaminocinnamate. The solution had a pH in excess of 12. 0.2 g of 5%-palladium-carbon was then added to the solution. After the gas phase in the vessel was purged with nitrogen and then with hydrogen, the reaction mixture in the vessel was subjected to catalytic reduction at 40°-45° C. under atmospheric pressure. The time required for the reduction was approximately four hours. After completion of the reduction, the reaction mixture was treated in the same manner as in Example 1 to obtain 9.91 g of N-acetylphenylalanine as a white crystal. Its melting point was 149.5°-150.5° C.
後処理
- customIn a 100-ml tightly-sealed glass vessel
出典と根拠
- ORDレコード
- ord-76e574437a3346ffb9e6a4987fee15f3
- 出典データセット
- uspto-grants-1986_09
- 特許番号
- US04612388
関連ノート
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