4-Methylbenzoyl Chloride → N'-[(4-methylphenyl)carbonyl]-3-nitrobenzohydrazide

HRID 651396

反応式

HRID 651396 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([NH:9][NH2:10])=[O:8])([O-:3])=[O:2].[C:14]1([CH3:23])[CH:19]=[CH:18][C:17]([C:20](Cl)=[O:21])=[CH:16][CH:15]=1>N1C=CC=CC=1>[CH3:23][C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:10][NH:9][C:7](=[O:8])[C:6]2[CH:11]=[CH:12][CH:13]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)=[O:21])=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 134054-Methylbenzoyl ChlorideHCID 32914983-Nitrobenzohydrazide

生成物 1

HCID 4506110N'-[(4-methylphenyl)carbonyl]-3-nitrobenzohydrazide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 3-nitrobenzhydrazide (2.16 g, 11.92 mmol) in pyridine (40 ml) cooled to 0° C. in an ice bath is added dropwise p-toluoyl chloride (1.94 g, 11.92 mmol). The mixture is allowed to warm to room temperature and stirred for 12 hours. The mixture is quenched with 350 mL of water and stirred for thirty minutes. The precipitate is filtered and dried in a vacuum oven to yield 1-[(4-methyl)benzoyl]-2-(3-nitrobenzoyl)hydrazine as a pale yellow solid. (2.94 g, 82%). 1H MMR (DMSOd6): δ 2.40 (s, 3H), 7.35 (d, 2H), 7.86 (d, 2H), 7.87 (t, 1H), 8.37 (d, 1H), 8.45 (d, 1H), 8.76 (s, 1H), 10.58 (s, 1H), 10.90 (s, 1H).

後処理

  1. customThe mixture is quenched with 350 mL of water
  2. stirringstirred for thirty minutes
  3. filtrationThe precipitate is filtered
  4. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-77427c6459dd44348c8490a76c1c2b90
出典データセット
uspto-grants-2001_08
特許番号
US06281217B1

関連ノート

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