Mandelic Acid → Sotalol

HRID 651495

反応式

HRID 651495 の反応式
[CH3:1][CH:2]([NH:4][CH2:5][C@@H:6]([OH:18])[C:7]1[CH:12]=[CH:11][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=1)[CH3:3].Cl.C(O)(=O)C(C1C=CC=CC=1)O>>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:1]

参加物

3

反応物 2

HCID 1292Mandelic AcidHCID 165245Dexsotalol hydrochloride

生成物 1

HCID 5253Sotalol

実験手順

In addition, using chemical method as described by Le Garrec (1987), enriched d-sotalol hydrochloride and l-sotalol hydrochloride were prepared using mandelic acid and subjected to conversion to the base form, chiral separation and reconversion to hydrochloride salt was carried out. The details of these procedures are given below:

後処理

  1. customwere prepared
  2. customsubjected to conversion to the base form, chiral separation and reconversion to hydrochloride salt

出典と根拠

ORDレコード
ord-b1da450602074d29b7a1aa7f0ca08711
出典データセット
uspto-grants-2001_08
特許番号
US06281246B1

関連ノート

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