Potassium Carbonate → Sotalol

HRID 651496

反応式

HRID 651496 の反応式
[CH3:1][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:3].Cl.C(=O)([O-])[O-].[K+].[K+]>O>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:1]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 66245959-24-0

生成物 1

HCID 5253Sotalol

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

In 2 lit. round bottom flask, in 450 ml of water, (±) sotalol hydrochloride (200 g) was added under stirring at room temperature. Under stirring, a solution of 500 g of potassium carbonate in 300 ml of water was added. The stirring was continued for 48 hours. Solid material was separated to give 107 g of (±) sotalol.

後処理

  1. stirringUnder stirring
  2. customSolid material was separated

出典と根拠

ORDレコード
ord-83949e398a5643a2bda1cdc453c2439c
出典データセット
uspto-grants-2001_08
特許番号
US06281246B1

関連ノート

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