Trifluoroacetic acid → Pyrrolo[3,2-c]pyridin-1-yl-acetic acid

HRID 651627ノート

反応式

HRID 651627 の反応式
C([O:5][C:6](=[O:17])[CH2:7][N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]=2[CH:10]=[CH:9]1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[N:8]1([CH2:7][C:6]([OH:17])=[O:5])[C:16]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]=2[CH:10]=[CH:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 54447290Pyrrolo[3,2-c]pyridin-1-yl-acetic acid tert-butyl ester

生成物 1

HCID 18176302Pyrrolo[3,2-c]pyridin-1-yl-acetic acid収率 150.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of pyrrolo[3,2-c]pyridin-1-yl-acetic acid tert-butyl ester (0.44 g, 1.89 mmol) in CH2Cl2 (10 mL) at 0° C. is added trifluoroacetic acid (1 mL). After 15 minutes, the solution is allowed to warm to room temperature and stirred for 18 hours. The reaction mixture is concentrated in vacuo and then azeotroped with toluene to give 0.5 g of the title compound as a residue (wet with excess TFA) which is used as is in the subsequent step

後処理

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customazeotroped with toluene

出典と根拠

ORDレコード
ord-70f83433f2d34839bb2a66a629b56a34
出典データセット
uspto-grants-2001_08
特許番号
US06281227B1

反応ノート

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