Methyl chloroglyoxylate → HCID 84741837、化合物

HRID 651757

反応式

HRID 651757 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1.Cl[C:14](=[O:19])[C:15]([O:17][CH3:18])=[O:16]>CCOCC>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:14](=[O:19])[C:15]([O:17][CH3:18])=[O:16])=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 79846Methyl chloroglyoxylateHCID 47779296-methoxy-1-methyl-1H-indole

生成物 1

HCID 84741837HCID 84741837、化合物収率 41%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

6-Methoxy-1-methyl-1H-indole (1.0 g, 6.19 mmol) was dissolved in ether (10 mL) and cooled to 0° C. Methyl chlorooxoacetate (1.17 mL, 12.4 mmol) was added dropwise. Stirring was continued at 0° C. for 6 h. The mixture was filtered and washed well with ether to give methyl (6-methoxy-1-methyl-1H-indol-3-yl)glyoxylate (621 mg, 41%).

後処理

  1. filtrationThe mixture was filtered
  2. washwashed well with ether

出典と根拠

ORDレコード
ord-ed957cc20c3948879785331dc05d89d3
出典データセット
uspto-grants-2001_08
特許番号
US06281356B1

関連ノート

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