Dimethylformamide → 2-(2-Chlorophenyl)-3-dimethylaminoprop-2-enal

HRID 65198

反応式

HRID 65198 の反応式
[CH3:1][N:2]([CH3:5])[CH:3]=O.P(Cl)(Cl)(Cl)=O.[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][C:19](O)=[O:20].C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18](=[CH:3][N:2]([CH3:5])[CH3:1])[CH:19]=[O:20]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 17124o-Chlorophenylacetic acidHCID 24813Phosphorus oxychloride

生成物 1

HCID 542093582-(2-Chlorophenyl)-3-dimethylaminoprop-2-enal

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

73 g of dimethylformamide are cooled to -50° C. 92 g of phosphorus oxychloride are added dropwise, followed by 34.2 g of 2-chlorophenylacetic acid, and the reaction mixture is stirred at room temperature for 30 minutes. It is then heated at 70°-80° C. for 5 hours 30 minutes. The reaction mixture is rendered alkaline with potassium carbonate, 200 ml of toluene are added and the mixture is heated in a water bath for 1 hour.

後処理

  1. temperatureIt is then heated at 70°-80° C. for 5 hours 30 minutes
  2. additionare added
  3. temperaturethe mixture is heated in a water bath for 1 hour

出典と根拠

ORDレコード
ord-9460d22982ec49918395afe4446371b9
出典データセット
uspto-grants-1986_09
特許番号
US04613603

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