Dichloromethane → 1-(Methoxycarbonyl)propyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate

HRID 652028

反応式

HRID 652028 の反応式
Cl.[CH3:2][Si:3]([CH3:29])([CH3:28])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1.C(Cl)Cl.[OH:33][CH:34]([CH2:39][CH3:40])[C:35]([O:37][CH3:38])=[O:36].C(N(CC)CC)C>CCOCC>[CH3:2][Si:3]([CH3:29])([CH3:28])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([O:33][CH:34]([C:35]([O:37][CH3:38])=[O:36])[CH2:39][CH3:40])=[O:24])=[CH:21][CH:20]=1

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 520445Methyl 2-hydroxybutanoateHCID 20198230HCID 20198230、化合物

生成物 1

HCID 201982671-(Methoxycarbonyl)propyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 10.0 g. 4-[14-(trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride in 200 ml. methylene chloride is added dropwise a solution of 3 g. methyl α-hydroxybutyrate and 5 g. triethylamine in 100 ml. ether. After 17 hours stirring at room temperature, the precipitate is collected and washed with several portions of ether. The ether solution is washed with water, dried and evaporated to yield the product as a white solid.

後処理

  1. customthe precipitate is collected
  2. washwashed with several portions of ether
  3. washThe ether solution is washed with water
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-703c8991bd5548c08ffbd47fb47e00ab
出典データセット
uspto-grants-1987_06
特許番号
US04670421

関連ノート

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