Sodium Hydroxide → N-[4-[14-(Trimethylsilyl)tetradecylamino]benzoyl)glycine

HRID 652032

反応式

HRID 652032 の反応式
[CH3:1][Si:2]([CH3:34])([CH3:33])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:32]=[CH:31][C:21]([C:22](=[O:30])[NH:23][CH2:24][C:25]([O:27]CC)=[O:26])=[CH:20][CH:19]=1.[OH-].[Na+]>C(O)C>[CH3:34][Si:2]([CH3:1])([CH3:33])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([NH:23][CH2:24][C:25]([OH:27])=[O:26])=[O:30])=[CH:31][CH:32]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 20198242Ethyl 4-[14-(trimethylsilyl)tetradecylamino]hippurate

生成物 1

HCID 20198286N-[4-[14-(Trimethylsilyl)tetradecylamino]benzoyl)glycine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 12.5 g. of ethyl 4-[14-(trimethylsilyl)tetradecylamino]hippurate, 55 ml. of 1N sodium hydroxide solutions and 50 ml. of ethanol is stirred at ambient temperature for 2 hours and then partially evaporated. The aqueous solution is washed with diethyl ether, acidified with 6N hydrochloric acid, and filtered. The solid is dried in vacuo and recrystallized to yield the product as a white solid.

後処理

  1. additionA mixture of 12.5 g
  2. custompartially evaporated
  3. washThe aqueous solution is washed with diethyl ether
  4. filtrationfiltered
  5. customThe solid is dried in vacuo
  6. customrecrystallized

出典と根拠

ORDレコード
ord-51d702da3ab148408fdf35a26672fdea
出典データセット
uspto-grants-1987_06
特許番号
US04670421

関連ノート

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