化工社化工社 化学情報印刷レポート · 研究参考用
Methanesulfonamide → N-[4-[14-(Trimethylsilyl)tetradecylamino]benzoyl]methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonamide | HCID 72879 | — |
| 反応物 | 4-[14-(Trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride | HCID 20198230 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-[4-[14-(Trimethylsilyl)tetradecylamino]benzoyl]methanesulfonamide | HCID 20198291 | — |
反応手順
A solution of 12.3 g. of 4-[14-(trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride and 2.8 g. of methanesulfonamide in 150 ml. of pyridine is stirred at reflux for 2 hours and then evaporated in vacuo. The residue is partitioned between water and diethyl ether, the aqueous layer acidified with 1N hydrochloric acid, and the organic layer separated, dried with magnesium sulfate and evaporated. Crystallization of the residue affords the product as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04670421 |
| 出典データセット | uspto-grants-1987_06 |
| ORD ID | ord-ae62468ef3c546e7b5459000a2be9856 |
| 出典メモ | uspto-grants-1987_06 |