関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tributylphosphine | HCID 13831 | — |
| 反応物 | 2-Propanol, 1,1'-(methylimino)bis- | HCID 95655 | — |
| 触媒 | Ruthenium trichloride | HCID 61850 | — |
| 溶媒 | Tetraglyme | HCID 8925 | — |
| 生成物 | 2,4,6-Trimethylmorpholine | HCID 19354342 | 90% |
反応手順
A 300 ml stirred autoclave with pyrex liner was charged a mixture of N-methyldiisopropanolamine (60 g, 0.41 mol), tributylphosphine (1.6 ml), ruthenium trichloride (0.520 g) and tetraglyme (30 ml). The reactor was sealed and purged of air. The reaction was heated to 180° C. and held for three hours. The reaction was allowed to cool to room temperature. The reaction mixtures were distilled to obtain a 90% yield of 2,4,6-trimethylmorpholine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04670557 |
|---|
| 出典データセット | uspto-grants-1987_06 |
|---|
| ORD ID | ord-22b47417fefe45d1b4f5fc0642a392d5 |
|---|
| 出典メモ | uspto-grants-1987_06 |
|---|
