Ammonia → 4-Cyclopropyl-6-(trichloromethyl)-1,3,5-triazin-2-amine
反応式
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([Cl:13])([Cl:12])[Cl:11])[N:7]=[C:6](C(Cl)(Cl)Cl)[N:5]=2)[CH2:3][CH2:2]1.[NH3:18]>O1CCCC1.O>[NH2:18][C:6]1[N:5]=[C:4]([CH:1]2[CH2:2][CH2:3]2)[N:9]=[C:8]([C:10]([Cl:13])([Cl:12])[Cl:11])[N:7]=1参加物
5
実験手順
71.2 g of 2-cyclopropyl-4,6-bis-trichloromethyl-1,3,5-triazine are dissolved in 70 ml of tetrahydrofuran, and at room temperature are added, with stirring, 300 ml of a concentrated aqueous ammonia solution. The reaction mixture is stirred for 30 minutes; it is then diluted with water, and the formed emulsion is extracted with ether. The ether phases are collected, dried, filtered and subsequently concentrated by evaporation. The residue crystallises and there remain 48 g of the crystalline title product, m.p. 111°-114° C.
後処理
- additionat room temperature are added
- stirringThe reaction mixture is stirred for 30 minutes
- extractionthe formed emulsion is extracted with ether
- customThe ether phases are collected
- customdried
- filtrationfiltered
- concentrationsubsequently concentrated by evaporation
- customThe residue crystallises
出典と根拠
- ORDレコード
- ord-ab9961fe241d441fbd156a2df11937c2
- 出典データセット
- uspto-grants-1987_06
- 特許番号
- US04670559
反応ノート
読み込み中…