Methanol → Boc-Phe-Gly-OH

HRID 652379ノート

反応式

HRID 652379 の反応式
[NH:1]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@H:2]([C:10]([NH:12][CH2:13][C:14]([O:16]CC1C=CC=CC=1)=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.CO>[Pd].CC(O)=O>[NH:1]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@H:2]([C:10]([NH:12][CH2:13][C:14]([OH:16])=[O:15])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 887MethanolHCID 15601613HCID 15601613、化合物

生成物 1

HCID 7014899Boc-Phe-Gly-OH収率 92.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

Boc-Phe-Gly-OBzl (6.2 g, 15 mmole) was suspended in the mixtured solvent of MeOH (80 ml) and AcOH (30 ml), and then H2 gas was passed through the solution in the presence of Pd-C for 4 hours. Pd-C was removed by filtration, and the solvent was distilled off. The thus-obtained residue was recrystalized two times with AcOEt/n-hexane to obtain the object product (4.49 g, 92.8%).

後処理

  1. customPd-C was removed by filtration
  2. distillationthe solvent was distilled off
  3. customThe thus-obtained residue was recrystalized two times with AcOEt/n-hexane

出典と根拠

ORDレコード
ord-775688068557490fb481461376de20d4
出典データセット
uspto-grants-1987_06
特許番号
US04670540

反応ノート

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