Ethyl chloroacetate → (4-Acetyl-3-hydroxy-2-propylphenoxy)acetic acid

HRID 652501ノート

反応式

HRID 652501 の反応式
[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([OH:11])[CH:5]=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13].Cl[CH2:16][C:17]([O:19]CC)=[O:18].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:12]([C:3]1[CH:4]=[CH:5][C:6]([O:11][CH2:16][C:17]([OH:19])=[O:18])=[C:7]([CH2:8][CH2:9][CH3:10])[C:2]=1[OH:1])(=[O:14])[CH3:13]

参加物

5

反応物 3

HCID 7751Ethyl chloroacetateHCID 11430Potassium CarbonateHCID 27751982',4'-Dihydroxy-3'-propylacetophenone

生成物 1

HCID 13753869(4-Acetyl-3-hydroxy-2-propylphenoxy)acetic acid

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 24.25 g of 1-(2,4-dihydroxy-3-propylphenyl) ethanone, 16.0 ml of ethyl chloroacetate and 26 g of anhydrous potassium carbonate in 375 ml of anhydrous acetone was stirred at reflux for 17 hours. The reaction mixture was filtered and the filtrate was concentrated in vacuo to an oil which was crystallized from ethanol to give 27.2 g of (4-acetyl-3-hydroxy-2-propylphenoxy)acetic acid, the titled compound, mp 61°-64°, (78% yield) in two crops.

後処理

  1. temperatureat reflux for 17 hours
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated in vacuo to an oil which
  4. customwas crystallized from ethanol

出典と根拠

ORDレコード
ord-eb7738d70d664d1fad7aaab46bea972b
出典データセット
uspto-grants-1987_06
特許番号
US04672066

反応ノート

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