Sodium Hydroxide → (4-Acetyl-3-hydroxy-2-propylphenoxy)acetic acid

HRID 652502ノート

反応式

HRID 652502 の反応式
C([O:3][C:4](=[O:20])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[C:9]([OH:16])[C:8]=1[CH2:17][CH2:18][CH3:19])C.[OH-].[Na+]>CO>[C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:20])=[O:3])=[C:8]([CH2:17][CH2:18][CH3:19])[C:9]=1[OH:16])(=[O:15])[CH3:14]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 13389144Ethyl (4-acetyl-3-hydroxy-2-propylphenoxy)acetate

生成物 1

HCID 13753869(4-Acetyl-3-hydroxy-2-propylphenoxy)acetic acid収率 82.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 5.6 g of (4-acetyl-3-hydroxy-2-propylphenoxy)acetic acid ethyl ester in 50 ml of methanol was added 50 ml of 1.0N sodium hydroxide and the solution was stirred at reflux for 2 hours. The methanol was removed in vacuo, the residue was acidified and the product was extracted with ether. The dried (over magnesium sulfate) extract was concentrated in vacuo to a solid which was recrystallized from ether-hexane to give 4.18 g of (4-acetyl-3-hydroxy-2-propylphenoxy)acetic acid, the titled compound, mp 128°-130°, (83% yield).

後処理

  1. temperatureat reflux for 2 hours
  2. customThe methanol was removed in vacuo
  3. extractionthe product was extracted with ether
  4. dry with materialThe dried (over magnesium sulfate)
  5. extractionextract
  6. concentrationwas concentrated in vacuo to a solid which
  7. customwas recrystallized from ether-hexane

出典と根拠

ORDレコード
ord-6e24e712a5d54b51bda708d08bd1aee4
出典データセット
uspto-grants-1987_06
特許番号
US04672066

反応ノート

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