Methyl iodide → HCID 178480903、化合物

HRID 65252

反応式

HRID 65252 の反応式
[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1.[I:20][CH3:21]>CO>[I-:20].[OH:1][CH:2]([C:9]1[CH:10]=[CH:11][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:13][CH:14]=1)[CH2:3][N+:4]1[CH:8]=[CH:7][N:6]([CH3:21])[CH:5]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 13763390N-[4-(1-Hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide

生成物 1

HCID 178480903HCID 178480903、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Heat a solution of 4.0 g (14.2 mmole) of (±)-N-[4-[1-hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide, 2 ml (32.1 mmole) of iodomethane and 50 ml methanol in a glass pressure tube to 80° C. for 24 hours. Remove the solvent in vacuo. Crystallize the residue from acetone. Recrystallize from acetone to provide the title compound.

後処理

  1. customRemove the solvent in vacuo
  2. customCrystallize the residue from acetone
  3. customRecrystallize from acetone

出典と根拠

ORDレコード
ord-30a8001166504f31b5d5e17ea568ca6b
出典データセット
uspto-grants-1986_09
特許番号
US04613609

関連ノート

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