Water → Levamisole

HRID 652556

反応式

HRID 652556 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:5][CH:6]=1.O>CC(=O)C>[CH:1]1[CH:6]=[CH:5][C:4]([C@@H:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 962WaterHCID 3913(+-)-Tetramisole

生成物 1

HCID 26879Levamisole収率 116.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
15 °C

実験手順

To a refluxing solution of 20.43 g of tetramisole (0.1 mol) in 190 ml of 2-propanone and 10 ml. of water was added 15.9 g of L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (0.05 mol). The mixture was refluxed for another 5 minutes and cooled to 15° C. After 12 hours the precipitate was filtered off, washed with 2-propanone and dried under vacuo at 70° C., yielding 23.88 g of levamisole.L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (salt) (yield=91.6%) αD20 =-63.5° (c5, 1N HCl); mp. 127.6°-129.3° C.

後処理

  1. temperatureThe mixture was refluxed for another 5 minutes
  2. filtrationAfter 12 hours the precipitate was filtered off
  3. washwashed with 2-propanone
  4. customdried under vacuo at 70° C.

出典と根拠

ORDレコード
ord-9ada5955cb59420d9a38cff60d0bad85
出典データセット
uspto-grants-1987_06
特許番号
US04672126

関連ノート

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