(+-)-Tetramisole → Levamisole

HRID 652560

反応式

HRID 652560 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:5][CH:6]=1>CC(O)C.O>[CH:1]1[CH:6]=[CH:5][C:4]([C@@H:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:3][CH:2]=1

参加物

4

反応物 1

HCID 3913(+-)-Tetramisole

生成物 1

HCID 26879Levamisole収率 128.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3776Isopropanol溶媒

実験手順

A suspension of 31.73 g of L-N-[(4-methoxyphenyl)sulfonyl]-glutamic acid (0.1 mol) in 400 ml of 2-propanol and 20 ml of water was stirred and heated till all solid entered solution. Then there were added 20.43 g of tetramisole. The whole was stirred and heated till an homogeneous solution was obtained. The solution was further stirred for 4 hours while the temperature was allowed to reach room temperature. The precipitate was filtered off, washed with 100 ml of 2-propanol and 5 ml of water and dried under vacuo at 50° C., yielding 26.17 g levamisole.L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (salt) (yield 100.3%) αD20 =-62.8° (c5. 1N HCl); mp. 127.4°-129.1° C.

後処理

  1. temperatureheated till all solid
  2. stirringThe whole was stirred
  3. temperatureheated till an homogeneous solution
  4. customwas obtained
  5. stirringThe solution was further stirred for 4 hours while the temperature
  6. customto reach room temperature
  7. filtrationThe precipitate was filtered off
  8. washwashed with 100 ml of 2-propanol and 5 ml of water
  9. customdried under vacuo at 50° C.

出典と根拠

ORDレコード
ord-2181bdd87d0f4458807b62eae6ff54ce
出典データセット
uspto-grants-1987_06
特許番号
US04672126

関連ノート

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