Methyl iodide → 3-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]ethyl]-1H-imidazolium iodide

HRID 65257ノート

反応式

HRID 65257 の反応式
[N:1]1([CH2:6][CH2:7][C:8]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[I:19][CH3:20]>CO>[I-:19].[CH3:20][N:3]1[CH:4]=[CH:5][NH+:1]([CH2:6][CH2:7][C:8]2[CH:9]=[CH:10][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:12][CH:13]=2)[CH2:2]1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 137633971-[2-[4-[(Methylsulfonyl)amino]phenyl]ethyl]-1H-imidazole

生成物 1

HCID 704378243-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]ethyl]-1H-imidazolium iodide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Heat a mixture of 5 g (0.019 mole) of N-[4-[2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide, 5 mL of iodomethane and 25 mL of methanol in a pressure tube at 75° C. for about 24 hours. Cool the mixture to room temperature and remove the solvents in vacuo. Slurry the residue in acetone (50 mL) and filter and wash with acetone (100 mL). Drying provides the title compound, which may be recrystallized from methanol.

後処理

  1. temperatureHeat
  2. customremove the solvents in vacuo
  3. filtrationfilter
  4. washwash with acetone (100 mL)
  5. customDrying

出典と根拠

ORDレコード
ord-fad4675282cd4f8cb72bfde83d2e1fed
出典データセット
uspto-grants-1986_09
特許番号
US04613609

反応ノート

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