Isopropanol → HCID 20195166、化合物

HRID 652992ノート

反応式

HRID 652992 の反応式
[Na].Cl[C:3]1[CH:8]=[C:7](Cl)[N:6]=[C:5]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[N:4]=1.[CH:17]([OH:20])([CH3:19])[CH3:18]>>[C:13]1([CH3:16])[CH:14]=[CH:15][C:10]([C:5]2[N:6]=[C:7]([O:20][CH:17]([CH3:19])[CH3:18])[CH:8]=[C:3]([O:20][CH:17]([CH3:19])[CH3:18])[N:4]=2)=[CH:11][CH:12]=1

参加物

4

反応物 3

HCID 3776IsopropanolHCID 5360545SodiumHCID 12703697HCID 12703697、化合物

生成物 1

HCID 20195166HCID 20195166、化合物

実験手順

21.16 g of sodium are dissolved in anhydrous isopropanol and to this solution are added 95.64 g of 4,6-dichloro-2-p-tolylpyrimidine at 60°-65° C. over 15 minutes. The mixture is then heated to the boil and refluxed for a further 4 hours to bring the reaction to completion. Excess isopropanol is then distilled off and the residual oil is taken up in chloroform. The chloroform layer is washed with water, dried over sodium sulfate, and filtered. The solvent is then distilled off, affording 112 g of 2-p-tolyl-4,6-bis-isopropoxypyrimidine in the form of a yellowish oil which is purified by high vacuum distillation. The boiling point is 123° C./5.332 Pascal.

後処理

  1. temperatureThe mixture is then heated to the boil
  2. temperaturerefluxed for a further 4 hours
  3. customthe reaction to completion
  4. distillationExcess isopropanol is then distilled off
  5. washThe chloroform layer is washed with water
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. distillationThe solvent is then distilled off

出典と根拠

ORDレコード
ord-e1ab474c78db4f5a86f686416ce0396d
出典データセット
uspto-grants-1987_06
特許番号
US04674229

反応ノート

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