Tetrabutylammonium Fluoride → HCID 178418635、化合物

HRID 6531

反応式

HRID 6531 の反応式
C[Si]([C:5]#[C:6][N:7]1[C:12]([OH:13])=[C:11]2[CH:14]=[C:15]([NH:17][C:18](=[O:23])[C:19]([CH3:22])([CH3:21])[CH3:20])[N:16]=[C:10]2[N:9]=[CH:8]1)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[C:6]([N:7]1[C:12]([OH:13])=[C:11]2[CH:14]=[C:15]([NH:17][C:18](=[O:23])[C:19]([CH3:21])([CH3:20])[CH3:22])[N:16]=[C:10]2[N:9]=[CH:8]1)#[CH:5]

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 178418686HCID 178418686、化合物

生成物 1

HCID 178418635HCID 178418635、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 1.5 g of 3-trimethylsilylethynyl--4-hydroxy-6-pivaloylaminopyrrolo[2,3-d]pyrimidine in 100 mL of anhydrous tetrahydrofuran cooled to 0° C. are added under nitrogen 4.75 mL of 1M tetrabutylammonium fluoride in anhydrous tetrahydrofuran. After 5 minutes, the reaction mixture is allowed to attain room temperature and is then stirred for 2 hours. The solvent is removed under reduced pressure and the residue purified by chromatography over silica gel to yield 3-ethynyl-4-hydroxy-6-pivaloylaminopyrrolo[2,3-d]pyrimidine.

後処理

  1. customto attain room temperature
  2. customThe solvent is removed under reduced pressure
  3. customthe residue purified by chromatography over silica gel

出典と根拠

ORDレコード
ord-733afb349588418397c28c2bf0f606c4
出典データセット
uspto-grants-1993_09
特許番号
US05248775

関連ノート

読み込み中…