Sulfuric Acid → 5-Fluoro-2-nitrobenzonitrile

HRID 65329

反応式

HRID 65329 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].S(=O)(=O)(O)O.[N+:15]([O-])([O-:17])=[O:16].[K+]>>[C:5]([C:4]1[CH:3]=[C:2]([F:1])[CH:9]=[CH:8][C:7]=1[N+:15]([O-:17])=[O:16])#[N:6]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 678803-Fluorobenzonitrile

生成物 1

HCID 37564675-Fluoro-2-nitrobenzonitrile収率 86.5%

反応条件

温度
25 °C

実験手順

m-Fluorobenzonitrile (96.8 g., 0.8 mole) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3°-6° C., then allowed to warm to 25° C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5×250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102°-104° C.

後処理

  1. extractionextracted with chloroform (5×250 ml.)
  2. customdried
  3. customthe solvent removed
  4. extractionThe residue is extracted with pentane
  5. customdried

出典と根拠

ORDレコード
ord-8200ac9a36da4d00b9866cfd5bbd0eae
出典データセット
uspto-grants-1986_09
特許番号
US04613360

関連ノート

読み込み中…