Benzyl Alcohol → HCID 20194697、化合物

HRID 653431ノート

反応式

HRID 653431 の反応式
[CH2:1]1[C:10]2=[CH:11][CH:12]=[CH:13][C:8]3=[C:9]2[N:4]([C:5](=[O:14])[CH2:6][CH2:7]3)[C:3](=[O:15])[CH2:2]1.Cl.[C:17]1([CH2:23][OH:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:17]1([CH2:23][O:24][C:3](=[O:15])[CH2:2][CH2:1][C:10]2[CH:11]=[CH:12][CH:13]=[C:8]3[C:9]=2[NH:4][C:5](=[O:14])[CH2:6][CH2:7]3)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 3

HCID 244Benzyl AlcoholHCID 313Hydrochloric AcidHCID 13519806HCID 13519806、化合物

生成物 1

HCID 20194697HCID 20194697、化合物

実験手順

A solution of 1,2,6,7-tetrahydro-3H,5H-benzo[ij]-quinolizine-3,5-dione (20.1 g, 0.1 mole) in phenylmethanol (200 ml) is treated with a drop of concentrated hydrochloric acid. The mixture is refluxed 24 hours (or until the starting dione can no longer be detected by thin layer chromatography). The solution is cooled and concentrated at reduced pressure. The product is purified by flash chromatography to yield 1,2,3,4-tetrahydro-2-oxo-8-quinoline propanoic acid phenylmethyl ester.

後処理

  1. temperatureThe mixture is refluxed 24 hours (or until the starting dione
  2. temperatureThe solution is cooled
  3. concentrationconcentrated at reduced pressure
  4. customThe product is purified by flash chromatography

出典と根拠

ORDレコード
ord-846f941e5d60449dbdb53eae21814fae
出典データセット
uspto-grants-1987_06
特許番号
US04677112

反応ノート

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