Toluene → Methyl acetate hexane

HRID 653551

反応式

HRID 653551 の反応式
[N+]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1S(N)(=O)=O)([O-])=[O:2].NCP(=O)(OC(C)C)[O:17][CH:18](C)C.[C:26]1([CH3:32])C=CC=CC=1>>[C:26]([O:17][CH3:18])(=[O:2])[CH3:32].[CH3:8][CH2:9][CH2:4][CH2:5][CH2:6][CH3:7]

参加物

4

反応物 3

HCID 1140TolueneHCID 1385102-NitrobenzenesulfonamideHCID 13740526Dipropan-2-yl (aminomethyl)phosphonate

生成物 1

HCID 23449302Methyl acetate hexane

実験手順

10 g (0.58 mole) of 2-nitrophenylsulfonamide are suspended in 20 ml of toluene and heated to reflux temperature. 17.0 g (0.087 mole) of diisopropyl aminomethylphosphonate are added dropwise to the hot solution. The reaction mixture is then boiled under reflux for 10 hours, cooled and evaporated. Chromatographing the residue over silica gel with a 4:1 methyl acetate/hexane mixture gives 1.6 g of 2-(di-i-propoxyphosphonylmethylamino)-phenylsulfonamide in the form of a yellow oil.

後処理

  1. temperatureheated
  2. temperatureto reflux temperature
  3. temperatureunder reflux for 10 hours
  4. temperaturecooled
  5. customevaporated

出典と根拠

ORDレコード
ord-f0454959cd19471f87064f43432f0e9c
出典データセット
uspto-grants-1987_06
特許番号
US04677217

関連ノート

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