Benzyl Bromide → 3-Benzyl-5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine

HRID 653641ノート

反応式

HRID 653641 の反応式
[Br:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([CH2:11][CH3:12])[NH:10][C:5]2=[C:4]([CH3:13])[CH:3]=1.[H-].[Na+].[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CN(C=O)C>[CH2:16]([N:8]1[C:6]2=[N:7][C:2]([Br:1])=[CH:3][C:4]([CH3:13])=[C:5]2[N:10]=[C:9]1[CH2:11][CH3:12])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 193856485-Bromo-2-ethyl-7-methyl-1H-imidazo[4,5-b]pyridine

生成物 1

HCID 193856613-Benzyl-5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 10 g (39 mmol) of the product of Step C in DMF (70 mL) at rt was added NaH (1.3 g of an 80% oil dispersion, 43 mmol). After 20 minutes benzyl bromide (5.15 mL, 43 mmol) was added and the reaction was stirred for 16 hours. The mixture was poured onto 500 g of ice and the solid residue was filtered, washed with water and air dried to give the title compound.

後処理

  1. filtrationthe solid residue was filtered
  2. washwashed with water and air
  3. customdried

出典と根拠

ORDレコード
ord-e4c98d7ae65d4591b849fe96912872a0
出典データセット
uspto-grants-1992_07
特許番号
US05128327

反応ノート

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